(Sept 14): Gilead Sciences Inc. agreed to acquire Immunomedics Inc. for about $21 billion, a substantial premium for the maker of a promising breast-cancer therapy, and another big bet by Gilead that an innovative tumor-fighting drug can boost its fortunes.
The proposed $88-a-share deal values Immunomedics at more than twice its closing price of $42.25 on Friday. The New Jersey-based company makes a breast-cancer treatment called Trodelvy that gained approval from the U.S. Food and Drug Administration in April. Since then, its stock has soared on bets that the clearance could make Immunomedics an attractive takeover target.
Trodelvy’s approval came after clinical trial data showed it beat back triple-negative breast cancer for almost four months longer than chemotherapy in patients getting the medication as a third line of therapy. The hard-to-treat disease -- which accounts for about 10-15% of all breast cancers -- doesn’t respond to many of the current treatment regimens. Immunomedics plans to file for full approval of the medicine later this year.
“This acquisition represents significant progress in Gilead’s work to build a strong and diverse oncology portfolio,” Gilead Chief Executive Officer Daniel O’Day said in a statement.
The Immunomedics drug is a type of therapy researchers have been pursuing for decades, called an antibody-drug-conjugate, or ADCs. The idea is to create a safer, more targeted cancer drug with an antibody that binds selectively to a tumor and releases a toxin to kill it. In theory, the technology could potentially work for almost any tumor type.
O’Day said Gilead was interested in the drug because of it potentially broad implications.
“It is bit of a pipeline in a product,” O’Day said in a phone interview. In addition to its proven efficacy for triple-negative breast cancer, Trodelvy has potential in bladder cancer, hormone receptor positive breast cancer, lung cancer and several other tumor types, O’Day said.
After the FDA approved Trodelvy in the spring, Gilead started talking to Immunomedics about a partnership, O’Day said in an interview. Gilead was one of several companies involved in talks with Immunomedics, he said.
In the past two weeks the talks turned toward an outright acquisition, as Gilead and Immunomedics realized they could better achieve the full potential of the drug if it was under one company, O’Day said.
Faced with declining sales of its blockbuster hepatitis C treatments, Gilead has been making efforts to expand in oncology for several years. In 2017, it paid $11.9 billion to take over Kite Pharma, the maker of CAR-T cancer therapy Yescarta. But that treatment hasn’t seen the kind of stellar sales that analysts hoped for, and the slow start has increased pressure on Gilead to find a standout cancer treatment.
Gilead has been focusing on drugs that harness the immune system to fight tumors. Earlier this year, it paid about $4.9 billion for drugmaker Forty Seven and its experimental immunotherapy drug magrolimab. It has also forged agreements with companies including Arcus Biosciences Inc. and Jounce Therapeutics Inc., which are also working on experimental immuno-oncology treatments.
Foster City, California-based Gilead has been in the spotlight this year because of its antiviral therapy remdesivir, the first drug to gain clearance for treating Covid-19. Excitement over that drug caused Gilead shares to soar this spring and, in June, Gilead itself was reported to be in talks to combine with AstraZeneca Plc. The British drugmaker made its own bet on ADCs last year, investing in a lung and breast cancer therapy made by Japan’s Daiichi Sankyo Co.
Since then, however, investor enthusiasm has ebbed. Gilead suffered a setback in August after U.S. regulators failed to approve a rheumatoid arthritis treatment it is developing with Belgian biotech company Galapagos NV. Investors have also become less confident in the commercial potential for remdesivir.
At the close Friday, Gilead shares were up about 1% year-to-date, leaving the company with a market value of $82.2 billion.
Acquiring Immunomedics will give Gilead an immediate presence in the enormous market for drugs that treat solid tumors such as breast cancer, complementing its medicines like Yescarta that are focused on blood tumors.
“It is a really important moment for Gilead. It allows us to have an even clearer growth profile for the company outside of virology,” O’Day said. “This is a clear next growth driver for us.”
It is “very safe to say” the drug has multibillion-dollar sales potential, O’Day said.
Gilead’s offer, which is not subject to a financing condition, will be funded with about $15 billion in cash and about $6 billion in newly issued debt. The deal is expected to be neutral to Gilead’s adjusted EPS in 2023 and will add to earnings thereafter.
Lazard and Morgan Stanley advised Gilead. Centerview Partners and BofA Securities advised Morris Plains, New Jersey-based Immunomedics.